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Notwithstanding the impressive results that have been published to date, there is still a requirement for successful human trials to be completed prior to clinical translation
GLP-1 agonists have shown to reduce intrahepatic fat, liver enzymes, and inflammatory cytokines involved in fibrosis progression
Many patients also exhibited signs of poor metabolic health
Chromatography was performed on a Kinetex 2.6 m HILIC 100 , 100 2.1 mm internal diameter column (Phenomenex), with a constant flow rate of 250 l/min and a solvent gradient from 20% Mobile Phase B (50:45:5, ACN:H 2 O:100 mM AmFm in H 2 O) to 22% B at 5 min, 40% B at 10 min, 60% B at 13 min, 80% B at 15 min, and 99% B at 20 min
Despite the biological plausibility of vitamin A in supporting immune function, the findings do not currently support its use for sepsis prevention in this population (Manapurath et al., 2022)
Free Radical Biology and Medicine , 34 (7), 928936
