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Through GLP-1 receptor activation, tirzepatide stimulates glucose-dependent insulin secretion from pancreatic beta cells, suppresses inappropriate glucagon secretion from alpha cells, and delays gastric emptying to attenuate postprandial glucose excursions
The current study showed a decline in glutamate levels over time, in a brain area called the anterior cingulate cortex (ACC)
It works by producing short-chain fatty acids that stimulate colonic motility
Slocum, S.L., et al., Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet
Its purely acting on brain receptors
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