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While overdosing through food sources is nearly impossible, taking large doses via supplements or IV therapy can carry some risks

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10.1016/j.celrep.2021.109726 45 HuJ.ZhangY.YiS.WangC.HuangX.PanS.et al (2022)

[2] Intractable epistaxis was reported in a 61 year old woman with cardiovascular disease who was receiving topiramate 25 mg daily for lower extremity neuropathy

Impairment can affect energy metabolism and nerve function

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