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As a precautionary measure, the medication is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

More recently, a longitudinal study among 3,849 community-living older adults in Ireland found that low vitamin B 12 serum concentrations ( 258-601 pmol/L) (101)

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Because it specifically targets beta-3 receptors, AOD-9604 focuses on fat cells and avoids the broader metabolic effects of full-length growth hormone, making it especially useful for studying fat metabolism independently