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The formation of gamma-glutamylcysteine is the rate-limiting reaction in GSH synthesis and is feedback inhibited by GSH itself, a mechanism responsible for the regulation of cellular GSH concentration
3.6 MAPKAPK2 overexpression modulates the KEAP1/Nrf2/HO-1 axis under oxidative stress To elucidate the molecular mechanism underlying MAPKAPK2-mediated antioxidant protection, we examined the KEAP1/Nrf2/HO-1 regulatory axis in PIG3V cells upon H 2 O 2 -induced oxidative stress
Old collagen breaks down before new collagen matures
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The primary antibodies used are as follows: P53 (Proteintech, 60283-2-Ig), pSer46-P53 (CST, 2521), FOXO4 (Proteintech, 21535-1-AP), Ki-67 (D3B5) Rabbit mAb (Alexa Fluor 647 Conjugate) (CST, 12075), P21 (CST, 14074), -H2AX (Abcam, ab2254)
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