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Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling

Proper injection technique, site rotation, and appropriate dilution minimize reactions

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This occurs because the lipid peroxides generated during the process disrupt the normal lipid packing in the membrane, making it more rigid and less flexible

Only the two oppositely charged free head groups (carboxylic carbon and amino nitrogen) separated by a 4 spacer carbon unit were identified as a minimal structural feature requirement (Doring et al