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However, to date, no UK-specific national guideline exists that directly addresses switching from tirzepatide to semaglutide

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Despite the different doses of semaglutide and tirzepatide and timepoints studied, the results of SURMOUNT-5 and the Truveta Research study were consistent, namely that tirzepatide-based medications performed better than semaglutide-based medications: SURMOUNT-5 study : At 72 weeks, weight loss was 20.2% for Zepbound (tirzepatide AOM) compared to 13.7% for Wegovy (semaglutide AOM)