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Retatrutide is a relatively large molecule, and aggressive reconstitution can denature portions of it, reducing potency
The most important are the 78 kDa glucose regulatory protein (GRP78) and protein disulfide isomerase (PDI)
Han H-H, Wang H-M, Jangili P, Li M, Wu L, Zang Y, et al
In cell-based models it has been studied for interactions with NO/eNOS signalling, VEGFR2-mediated angiogenic pathways, and focal adhesion kinase (FAK)/paxillin complexes relevant to cell-migration assays
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