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Alongside their peroxidase activity, they may also function as molecular chaperones [45] and specific oxidases in signaling pathways through redox relay reactions [46,47]
Although the long-term prognosis for patients with symptomatic disease remains guarded, it is not uncommon to encounter patients living relatively normal lives many years after their symptoms first appeared. Attempts at treating childhood leptomeningeal melanoma with various antineoplastic regimens involving radiation and chemotherapy have not seemed to improve survival times significantly
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Extracellular relay and paracrine propagation Although direct membrane contacts and ROS-triggered waves provide two compelling frameworks for ferroptotic spread, neither fully explains how ferroptosis extends across anatomically separated yet functionally coupled cells
Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko K, Tomita M, Wanner BL, Mori H: Construction of Escherichia coli K-12 in frame, single-gene knockout mutants: the Keio Collection
