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FFA3 is expressed in the enteric sympathetic ganglion (Nhr et al., 2015) and the GLP-1R is expressed in vagal afferent neurons including the nodose ganglion (Zhang et al., 2020), suggesting the possibility of functional interactions between these two receptors at these neuronal locations
demonstrated that long-term GHRH analog administration in aging adults produced sustained increases in GH secretion and IGF-1 levels along with improvements in body composition (3)
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As background to the study, the investigators noted that there have been no previous direct comparisons between GLP- 1 RAs and metformin for preventing dementia in patients with type 2 diabetes
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