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3 Results In this study, we aimed to determine if three drugs from the SSRI family (sertraline, fluoxetine, and citalopram), commonly used as antidepressants (Figure 1, right panel), can be repurposed as inhibitors of MRP1 and MRP7 transporters (Figure 1, left panel) to overcome MDR in cancer cells

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While the cancer cells provide their microenvironment with secreted metabolites, sertraline treatment could target the galectin-1 mediated immunosuppressive marks of ser/gly metabolically dependent lung cancer [35, 67]

Before imaging, the cells were incubated with 100 nM TRaQ-G or TRaQ-G-ctrl ligand for 1 h in culture medium still containing thymidine

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