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Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells
NICEs original 30k/QALY threshold was designed to reflect the average NHS opportunity cost (the health that must be foregone when funding the drug)
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Both are supplied lyophilised (freeze-dried) for stability during transit
In mice bred to no longer produce GLP-1, for instance, their sensitivity to sweetness seems dramatically reduced
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