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Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden

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In contrast, transdermal delivery must overcome the skin's natural barrier function, which evolved specifically to prevent external substances from entering the body

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University of Michigan Medicine.