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The reasons for this disparity are not clear, but methodological differences are likely as we specifically sought evidence of beta cell desensitization by performing delayed IPGTTs

While there are a few studies that demonstrate potential influences of these compounds on blood sugar and weight, the evidence is far from conclusive or robust, says Martin Binks, PhD, a professor and the chair of the Department of Nutrition and Food Studies at the George Mason University College of Public Health

You may be a candidate for some versions of semaglutide if you have Type 2 diabetes, your A1C level is uncontrolled, youre at risk of cardiovascular disease, and you have heart failure or kidney disease

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Kim MS, Kim WJ, Khera AV, et al