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The results demonstrated that genetic liability to type 2 diabetes was significantly associated with an elevated risk of 12 gastrointestinal conditions, including gastroesophageal reflux disease, gastric ulcer, acute gastritis, chronic gastritis, irritable bowel syndrome, diverticular disease, acute pancreatitis, cholelithiasis, cholelithiasis with cholecystitis, nonalcoholic fatty liver disease, liver cirrhosis, and ulcerative colitis [70]

11, 13 There have been early studies by Krner et al 2 that found species differences for GLP1R expression in thyroids and lungs, with a much higher expression in the thyroid and lungs of rat and mouse than in the corresponding human organs

It is not approved or reviewed by the U.S

However, its superior efficacy may justify the cost for many patients

PlexusDx makes semaglutide accessible through licensed 503A compounding pharmacies at rates at $189/mo month-to-month, or from $149/mo on the 6-month plan, with no insurance requirement or membership fees

For many patients without insurance coverage, compounded tirzepatide through a licensed clinic or telehealth provider is still the more accessible route