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Similar in vitro work showed that HGF promoted dendritic arborization in hippocampal neurons, an effect that could be blocked by NMDA receptor antagonists and was dependent on intracellular calcium and CaMKII activity [2]
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Biochemistry 50 , 58705882 (2011)
This ultimately decreases albumin leakage into the retina, thus improving the vascular permeability and preventing the capillary degeneration and pericyte loss typically seen in DR
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Standard oral formulations achieve only 0.7% bioavailability, limiting blood level increases compared to IV delivery
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