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Post-market surveillance data continues to accumulate, and individual case reports exist, but large-scale epidemiological studies have not yet demonstrated that these drugs cause depression at rates higher than would be expected by chance
These conditions include diseases such as hypertension (high blood pressure), diabetes, high cholesterol levels, heart disease, and sleep apnea
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Second, post-marketing data reveal that real-world adherence and persistence are lower than in clinical trials, often due to gastrointestinal side effects, treatment fatigue, or cost-related barriers (143145)
Stability can be affected by formulation, storage, heat and oxidation
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