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Low-fat areas such as the inner thigh, the lower abdomen in leaner individuals, and sites near bony prominences should be avoided where possible as they offer less tissue cushioning and produce more pronounced discomfort

and Neel, B.G

These endogenous protective mechanisms provide potential intervention targets for heart failure-associated brain injury and neuroinflammation, revealing the central role of mitochondrial functional integrity in maintaining homeostasis along the heartbrain axis