M.LipskyR
Metformin promotes anxiolytic and antidepressant-like responses in insulin-resistant mice by decreasing circulating branched-chain amino acids
Exclusion criteria were a history of bariatric surgery, alcohol use disorder identification test (AUDIT) greater than 16, hemoglobin A1c measurement greater than 9, a history of seizure disorder or traumatic brain injury, on specific medications that interfere with alcohol metabolism such as certain antibiotics (reviewed on a case-by-case basis by study physician), or currently pregnant or lactating
Nausea typically resolves or becomes minimal, and your appetite remains suppressed at a sustainable level
The medication may reduce appetite, improve fullness, slow gastric emptying, and support blood sugar regulation, but if calorie intake creeps back up, weight loss can stall
The frequency of gastrointestinal side effects is higher with retatrutide (nausea affects about 43% vs 12-33% for Mounjaro)