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This does not invalidate clinical use

How they interplay is so important

Tesamorelin is a synthetic growth hormone-releasing hormone analogue used in some countries for HIV-associated lipodystrophy, whilst retatrutide is an investigational triple receptor agonist (GLP-1, GIP, and glucagon) currently in Phase 3 trials

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doi:10.1016/j.ando.2007.03.003

Wegovy is licensed in the UK in doses up to 2.4mg for weight loss and, on 14 September 2025, Novo Nordisk published results of a phase IIIb clinical trial (STEP UP, NCT05646706) of a 7.2mg dose of semaglutide for subcutaneous injection 1