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doi:10.1002/anie.202301209 Hirschmann, Ralph F et al
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This action makes these agents a therapeutic option for weight loss.56 Although to a lesser extent, delay in gastric emptying contributes to the anorexigenic effect.61 Clinical trials conducted with GLP-1 receptor agonists in patients with obesity (or excess weight [BMI 27] with comorbidities), or with DT2 and excess weight or obesity, have achieved weight reductions greater than those reported for orlistat, as well as those observed with oral antidiabetic agents such as the sodium glucose type 2 cotransporter inhibitors (SGLT2i) or metformin.62 In a meta-analysis of more than 10 000 patients with obesity, those treated with GLP-1 receptor agonists lost, on average, 7kg more than those in the control group.63 Weight loss of up to 15% has been observed after 12 months of treatment,64,65 a level that had only been achieved through surgical methods
Dopaminergic neurons are particularly susceptible to oxidative stress due to the metabolism of dopamine
R., Wilson, C
Moreover previous results suggested that BMS21 does not engage the orthosteric binding site of the ECD and we showed that a closely related analogue of BMS21 does not interact with the isolated ECD (see Supplementary Fig
