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Pathological astrocytes, when mixed with healthy neurones, can, on their own precipitate neuronal death, again indicating a leading role of astrocytes in pathophysiology of ALS

Only when B12 injections became available was folate treatment abandoned, leaving many victims with irreversible B12-deficiency-related neurological damage

Disturbances in GSH homeostasis have been implicated in neurodegenerative disorders, liver disease, cystic fibrosis, pulmonary and cardiovascular diseases, as well as the chronic age-related diseases and the aging process itself.Recent data also suggests it plays a role in metabolic and inflammatory diseases such as multiple sclerosis, the metabolic syndrome, and diabetes, at least in part by influencing the effect of multiple environmental toxins, an underappreciated yet surprisingly significant association

10.1080/14786419.2015.1012717 212 ZulkhairiA