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However, what is well established is that overweight and/or obesity are strongly associated with male infertility in several overlapping ways

10.1007/s00592-018-1271-3 13

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At the highest dose of 12 mg retatrutide, the average weight loss after 48 weeks was 24.2% with reduction up to 30% from the baseline weight in 25% of participants

This could potentially be run as a single study with the induction trial proposed above, however we would suggest that results be published in two phases so that the very short-term induction data is not held back while waiting for success rate data

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