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There is no indication that long-term use changes this fundamental characteristic

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Diarrhea: Intestinal transit can become irregular or accelerated in some patients, leading to diarrhea that is typically mild to moderate and temporary

The comparative effectiveness of these medications indicates that, while both tirzepatide vs retatrutide are beneficial, the dual mechanism of action of retatrutideaffecting appetite and fat cell metabolismmay provide an alternative approach to managing body mass

Importantly, NHS funding for Saxenda is restricted by NICE Technology Appraisal 664, which specifies that treatment should only be initiated within specialist tier 3 weight management services