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Reduction in Risk Across Fourteen Obesity-Related Cancers A large observational study presented at the American Society of Clinical Oncology (ASCO) Annual Meeting 2025, involving more than 170,000 patients with diabetes and obesity, found that GLP-1 receptor agonists were associated with a modest but statistically meaningful reduction in the incidence of 14 obesity-related cancers , with colorectal cancer demonstrating particularly favourable outcomes when compared to patients receiving DPP-4 inhibitors
Results: FPG in the L-carnitine group decreased significantly from 14335 to 13033 mg/dl ( P =0.03), and we observed a significant increase of triglycerides (TG) from 19661 to 23312 mg/dl ( P =0.05), of Apo A1 from 9420 to 10323 mg/dl ( P =0.02), and of Apo B100 from 9818 to 10822 mg/dl ( P =0.02) after 12 weeks of treatment
Keenan, E
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Whilst the concept of combining agents that target different metabolic pathways is well established in conditions such as type 2 diabetes, there is no specific peer-reviewed evidence supporting the combination of GH-axis modulators with incretin-based therapies in obesity or metabolic-associated steatotic liver disease (MASLD)
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