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To qualify, you need to meet one of the following requirements when starting GLP-1 treatment: A BMI (body mass index) of 35 or higher A BMI between 30 and 34.99, with one or more additional conditions: Diastolic heart failure Uncontrolled high blood pressure/hypertension Chronic kidney disease, stage 3a or higher Prediabetes Previous heart attack or stroke Blocked arteries in arms or legs with symptoms A BMI between 27 and 29.99, with one or more additional conditions: Prediabetes Previous heart attack or stroke Blocked arteries in arms or legs with symptoms Medicare beneficiaries who have sleep apnea, diabetes or fatty liver disease can't access the program, but their Medicare Part D insurance might cover their GLP-1s separately based on those diagnoses

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Methyl donor deficiency impairs fatty acid oxidation through PGC-1alpha hypomethylation and decreased ER-alpha, ERR-alpha, and HNF-4alpha in the rat liver