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Further subgroup analyses based on the dosage and duration of treatment also demonstrated no significant SMD in any subgroups (Supplementary Figure 1)

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lateral ventricle and medial preoptic area injections demonstrated local effects The subcutaneous route ultimately proved most suitable for clinical development, offering reliable absorption, manageable side effects, and practical at-home self-administration

Providers should reassess B12 blood levels every 3 to 6 months to determine whether continued injections are warranted

Non-ablative fractional lasers : Stimulate skin remodelling and may assist with diffuse pigmentation improvement over a series of treatments