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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation
The 4.5 mg dose produced 10.8% reduction (11.5 kg average)
Burnette EM, Nieto SJ, Grodin EN, Meredith LR, Hurley B, Miotto K, et al
Glutathione plays a critical role in protecting cells from oxidative stress while also supporting the bodys natural detoxification systems
Covalent inhibitors represent a different strategy, where the inhibitor forms a permanent bond with the enzyme, leading to irreversible inhibition
