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Compounding medications is allowed in several circumstances, including: if the patient requires a different dosage form or strength of a medication than what is commercially available, or if a medication is currently on manufacturer shortage
While not specific to semaglutide, these cases highlight the dangers of using compounded medications without proper oversight
Oral administration does not work: digestive enzymes destroy the peptide before absorption, leaving bioavailability below 5%
If you have experienced these symptoms recently, your fluid balance may be compromised, increasing the risk of donation-related adverse events such as vasovagal reactions, dizziness, or fainting
There are some potential biases in these data that we need to be cautious about, but this gives us some valuable insights about the risk profile of these agents that can inform subsequent studies perhaps even a randomized controlled trial that can tease out the specific mechanisms and provide more conclusive evidence. Reduced risk overall GLP-1 receptor agonists have been approved in the United States to treat diabetes since 2005 and obesity since 2014
Roberts et al., 2017a
