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Additional restrictions to the widespread use of GLP-1 RAs and dual GIP/GLP-1 RAs include high treatment costs and limited accessibility in many healthcare systems

Fc fusion to glucagon-like peptide-1 inhibits degradation by human DPP-IV, increasing its half-life in serum and inducing a potent activity for human GLP-1 receptor activation

Orer GE et al

Additionally, retatrutide significantly improved blood lipids and blood pressure compared to placebo

PlexusDx patients interested in understanding their individual responsiveness to GLP-1 therapy can explore the Precision Peptide Genetic Test, which analyzes variants in related dopamine-pathway genes to identify predisposition to treatment response

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