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However, the bioequivalence criterion for the AUC was met for ethinylestradiol in all cases, and the AUC for the progestin component was either unaffected or showed approximately 20% higher mean exposure, which is not considered to affect the safety or efficacy of the combined pills
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16 The tentative conclusion that alterations in postprandial GLP-1 dynamics might contribute to such effects of sleep loss is supported by findings in rats that the GLP-1 analog exendin-4 decreases the rewarding value of food
