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In response to these findings, in 2018 European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) consensus guidance provides a decision cycle for patient-centered management of T2DM, taking into account not only key patient characteristics (age, weight, CVD, and renal history), but also specific factors such as HbA1c lowering effect, hypoglycemic risk, effect on weight, side effects, complexity, costs, and cardiorenal effects

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This effect and the failure to maintain suppressed GIP levels, as seen in PAR2-G37I mice, may compromise obesity protection in PAR2-R38E mice