Until that qualification work is done, the imaging and fluid measures are instruments for understanding the mechanism and selecting patients, while the question of whether these drugs modify the disease still belongs to the clinical endpoints
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In the STEP 1 trial , 1,961 adults with a BMI of 30 or higher (or 27 with weight-related health conditions) took weekly doses of Semaglutide 2.4 mg for 68 weeks
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5 Figure 3: Pharmacy claims data show that 63% of patients initiating Wegovy or Zepbound in early 2024 remained on therapy at one year, up from 40% in the 2023 cohort