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With newer GLP-1based therapies now emerging, the field has an opportunity to test whether different drugs in this class have distinct effects on aging biology and to identify which patients may benefit most. Larger clinical trials are needed to confirm the findings, determine how long treatment effects last, and establish optimal dosing and treatment duration for both people with HIV and the broader population

Participants are usually adults with obesity or significant metabolic disease, often with additional criteria such as insulin resistance or cardiovascular risk factors

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Energy demands increase during stress due to the fight or flight response and allostatic biological systems, both of which rely on adenosine triphosphate (ATP) as an energy source