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Semaglutide 2.4 mg (Wegovy): ~15% body weight loss at 68 weeks in clinical trials Tirzepatide 15 mg (Zepbound): ~21% body weight loss at 72 weeks in clinical trials Real-world data shows lower results: Cleveland Clinic research from 2025 found average weight loss of 7.7% with semaglutide and 12.4% with tirzepatide at one year in routine clinical practice

doi: 10.1530/eje-12-1037 30 CopinschiGNedeltchevaALeproultRMorselliLLSpiegelKMartinoEet al

Many patients notice improvements in sleep and energy within the first few weeks, with continued benefits developing over several months

Dietary supplements, known more for supporting weight maintenance than rapid weight loss, are uniquely positioned to meet this demand, making them a strategic focus for brands looking to serve a motivated and growing audience

More significant inflammation-related changes typically occur over several months as metabolic health improves and body fat decreases