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Gerontology (1999) 45(3):13642

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HEPES [(2-hydroxyethyl) piperazine-1-ethanesulfonic acid] was found to be the most potent protector compared to human tubal fluid media and polyvinyl alcohol against DNA damage occurring in spermatozoa, as determined by plasmid relaxation assay which measures the plasmid DNA damage [174]

These compounds are known to have significant adverse effects on human health as exposure, particularly developmental exposure, has been associated with cognitive deficits, neurological disorders, reproductive abnormalities, metabolic diseases/disorders, obesity, and diabetes 5

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GLP-1 receptor agonists and colorectal cancer risk in drug-naive patients with type 2 diabetes, with and without overweight/obesity