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Storage duration critically impacts effectiveness - reconstituted GHK-Cu lasts only 21-28 days refrigerated due to copper oxidation concerns (shorter than most peptides), requiring strategic reconstitution of amounts usable within this window rather than preparing entire vials at once

However, the effect of oral vitamin B 12 varies among patients (13), and the available randomized controlled trials comparing the two treatment regimens are considered to be of low quality (14)