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But for the subset of patients who do develop genuine statin myopathy, concurrent GLP-1 therapy and its associated electrolyte shifts can lower the threshold for symptomatic cramping

Similarly, injecting into the same spot repeatedly creates scar tissue and lipohypertrophy, both of which impair medication uptake and may require dose adjustments to maintain efficacy

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Last reviewed: May 21, 2026 Last updated: May 21, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Blood Sugar Changes Trials showed more tesamorelin users had elevated HbA1c (a 3-month average blood sugar marker) compared to placebo