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In rodent models, peripheral administration of exendin-4 (EX4), a GLP-1RA has been shown to reduce motivation for sucrose, as evidenced by decreased responding in progressive ratio operant-conditioning tasks (Dickson et al., 2012)

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When appetite drops hard, it is easy to under eat protein without noticing, and that is the fast track to losing muscle along with fat

We combine tirzepatide with metabolic monitoring and nutritional support rather than relying on medication as a standalone intervention

Phase 2 trial data (Jastreboff et al., NEJM, 2023) showed mean body weight reductions of approximately 24% at 48 weeks with the highest dose, with no clear plateau observed