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Decision factors: Weight loss goals: Want maximum weight loss and can tolerate side effects: Tirzepatide (Zepbound) shows ~4% greater weight loss than semaglutide on average Want proven cardiovascular benefits: Semaglutide has demonstrated 20% reduction in major cardiovascular events in the SELECT trial Want to try oral option: Oral semaglutide (Rybelsus) for diabetes, though weight loss is less than injectable Side effect sensitivity: Some people tolerate one better than the other
SCFAs are grouped under the definition of postbiotic, and play a key role in regulating fat metabolism, supporting the function of insulin and reducing inflammation in the gut and beyond
PubMed record Mischley LK, Lau RC, Shankland EG, et al
Bullock, A
Only one study showed no residual gastric contents in all patients taking GLP-1 receptor agonists after having the patients fast from solids for 24 hours and from liquids for 12 hours (n=57)
Hajjar et al., 2018
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