Knop, Glucose-dependent insulinotropic polypeptide: blood glucose stabilizing effects in patients with type 2 diabetes
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It helps control blood sugar levels in people with diabetes thereby preventing serious complications of diabetes such as kidney damage and blindness
What they did: Obese mice received AOD-9604 orally (via gavage) for 14 days at various doses (50, 250, 500 g/kg)
In the SURPASS clinical trial program for type 2 diabetes, diarrhea occurred in approximately 12-16% of patients receiving tirzepatide across various doses (5 mg, 10 mg, and 15 mg weekly), compared to lower rates in comparator groups