independent groups reported negative results at the same dose
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"KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114
The FTO gene variant rs9939609, for example, affects metabolic rate and heat production independent of weight, which means some patients may feel colder than others at the same dose and weight loss stage
Geroscience 47 , 44134427 (2025)
Interestingly, it has been found that this syndrome can also be caused by a mutation in the mitochondrial ribosomal protein MRPS22 with deficiencies of OXPHOS complexes I, III, and IV in fibroblast mitochondria [392]