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Resistance training also improves insulin sensitivity independent of weight loss, which supports better metabolic function and may complement GLP-1 receptor resensitization

Matthews VL, Knutsen SF, Beeson WL, Fraser GE

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Compared to popular GLP-1RAs like semaglutide, orforglipron does not require injection or an absorption enhancer with fasting to achieve exposure, and it can be taken without water or food restrictions, according to Phase 1 pharmacokinetic data