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Probe phospho/PTM signal and total target protein

8 Tirzepatide received FDA approval in 2022 as Mounjaro for the treatment of type 2 diabetes

It works as a GLP-1 receptor agonist, mimicking the GLP-1 hormone to slow gastric emptying, stimulate insulin production, inhibit glucagon, and act on appetite-regulating centers in the brain

Semaglutide had more discontinuations within 6 months of starting the first GLP-1RA, compared to liraglutide (63.4% vs