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However, as we age typically after the age of 25 collagen production gradually declines

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Only a minor increase in ALT activity was observed in Normal cells, thereby showing that it was specific to cancer cells

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extrahepatic manifestations, such as diarrhoea, pancreatic disease, rickets, pneumonia, abnormal sweat tests, hearing impairment, and poor growth have been described in PFIC1 patients [2]