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The clinical trials showing 14.9% average weight loss used the 2.4 mg dose, so Wegovy has a slight theoretical advantage

The active ingredient in Mounjaro, tirzepatide, works like two types of incretin hormones that your body naturally produces

Cardiovasc Diabetol (2016) 15(1):162

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Recent research has shown that hyperglycemia induced cellular stress, such as ERS (120) and oxidative stress (119), which stimulate the pyroptotic process in renal cells, and various signaling pathways, such as TLRs/NF-B/NLRP3 inflammasome signalling pathway, TXNIP/NLRP3 inflammasome pathway, ATP/P2X purinergic signalling pathway, and MAPKs/NLRP3 inflammasome signalling pathway (119, 121)