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Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

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These antioxidant responses have clear relevance to DR, as elevated SOD, catalase, and glutathione peroxidase levels correlate with reduced oxidative injury in retinal tissues, and inhibition of NADPH oxidase effectively prevents pathological ROS overproduction (61, 152, 153)

Doi: 10.1371/journal.pone.0210389

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