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This substitution resulted in a peptide bond between D-Ala and the 3rd amino acid in the structure aspartic acid (Asp) more able to resist rapid cleavage by the enzyme dipeptidyl peptidase-4, a cleavage which had previously led to an inactive peptide fragment

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Roehnelt explains how insulin functions in the body, what happens when insulin resistance develops, and why chronically elevated insulin drives inflammation, weight gain, metabolic dysfunction, and disease progression

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