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One large placebo-controlled trial (presented at the AUA meeting in 2007) tested intranasal bremelanotide in 726 men with ED (average age 55) over 12 weeks

Meier JJ (2021) Efficacy of semaglutide in a subcutaneous and an oral formulation

The second mechanism involves the nuclear transcription factor NRF2 (nuclear factor erythroid 2-related factor 2), which governs the cell's antioxidant defense network

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