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He underscored the importance of focusing treatment on high-morbidity and high-mortality populations related to metabolic syndrome and establishing effective long-term treatment models

The cultural and emotional implications of the drugs weight-loss effects, especially shame, became a recurrent theme

It shows you're thinking carefully about your health choices

The caloric deficit is simply too large

In 2,339 participants at the 12mg dose, the safety profile was consistent with TRIUMPH-4 and GLP-1 class expectations with one important improvement: discontinuation due to side effects dropped to 11.3% , compared to 18.2% in TRIUMPH-4's osteoarthritis population

However, these side effects do subside over time